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Phosphocreatine buffers cerebral ATP as in muscle; a 0.35g/kg dose preserved processing speed across 21 h of sleep deprivation. Domain effects are inconsistent. Emerging, not established.
Pooled across 12 trials, creatine plus training added 1.14 kg lean mass (95% CI 0.69 to 1.59) and reduced fat mass 0.73 kg versus training alone. Pooled body-composition effect size ~0.17.
Across 22 studies, creatine with resistance training exceeded placebo by ~8% for maximal strength (20% vs 12%) and ~14% for weightlifting performance. ISSN: safe to 30g/day over five years.
The clinical default. Muscle saturates in 3 to 4 weeks; timing doesn't matter.
10g
Daily
Enhanced Protocol
Higher sustained intake targets cerebral stores. Split into two 5g doses if GI tolerance is an issue.
20g
1 to 5 days
Acute cognitive loading
Short-term, for sleep loss or jet lag. Split across the day.‡
How to take it
Mix 1 to 2 scoops (5 to 10g) with 8 to 12 oz of water or a shake until dispersed. Unflavored.
Every lot is produced under strict cGMP controls in FDA-registered facilities and tested for identity, heavy metals, and microbial safety before release. Results are published for every batch we ship.
Finished product is held in temperature-controlled storage and shipped from a climate-controlled facility, in sealed, tamper-evident packaging.
✓NSF GMP-certified manufacturing facility
✓SQF-certified manufacturing facility
✓FDA 21 CFR Part 111 compliant
✓Physician-formulated, panel-reviewed before release
Customers rate CM-01 five stars and call it the cleanest creatine they have used. Reviewers describe an ultra-fine powder that dissolves fast and completely, truly unflavored in water, coffee, or a shake. They point to the single-ingredient formula, the ≥99.9% tested purity, and the published certificate behind every lot, and they report real results in strength, recovery, and daily focus. Most say it has become a permanent part of their routine.
Customer Photos
Customers Talked About
Mixability
Purity
Strength
Endurance
Cognition
★★★★★★★★★★
Best creatine I’ve had. I usually struggle with digesting creatine as it gives me nausea. This is the first creatine that I’ve had that I’m able to consume and process totally fine. Strongly recommend you try it if you’ve had similar experiences with your body reacting to creatine in the past.
ArmandVerified buyer
★★★★★★★★★★
Really impressed with this creatine. The powder is extremely fine, mixes quickly without leaving much grit behind, and the unflavored formula makes it easy to add to anything. I also like that it contains just one ingredient and is third-party tested for purity and contaminants. It feels like a well-made, dependable product, and I would buy it again.
AlexanderVerified buyer
★★★★★★★★★★
I've tried many different creatine brands over the years, and this is easily the best I've used. I appreciate that it's a single, clearly labeled ingredient with no fillers. It dissolves completely with no grit at the bottom of the glass, and the flavor is clean without any gross aftertaste. Highly recommend to anyone serious about their supplement intake.
AndyVerified buyer
★★★★★★★★★★
Believe me when I say I did not expect a creatine to change my whole morning, and yet here we are. I'm a mom of two and I've been lifting consistently for ten years, which means I've choked down more chalky, gritty, floating-on-top-of-the-water creatine than I care to admit. The kind that you painstakingly chug, and there's still a little sand dune of undissolved powder waiting for you at the bottom.
Well, not this one. It is the most fine powder that dissolves perfectly into just a few ounces of water. No grit, no clumps, no gross sandy last sip. For the first time in a decade I don't have to psych myself up to take my creatine, so I'm actually take it. I'm 30 days in and I've been more consistent with this one than any creatine I've ever used. I've even started going to the gym 4 days a week, and I haven't gone more than 3 since having kids. Also, ZERO stomach issues! none of the GI problems or bloating I've dealt with from other creatine brands.
My only complaint is that my husband has started stealing it. He has his own creatine sitting right there in the pantry, untouched and dbandoned. Because he decided mine is better and now we're apparently sharing a bag I did not agree to share. So if you buy this, maybe buy two. One for you, and one for the person in your house who's about to develop a sudden interest in your supplements.
GwenVerified buyer
★★★★★★★★★★
As a dentist, I appreciate just how scientific and medical this company is. I appreciate the fact that all their products are tested. Their creatine doesn’t have a taste and mixes so easily. Can’t wait for their next stuff.
DAVIDVerified buyer
★★★★★★★★★★
I’ve been really happy with AntiLabs creatine powder! It mixes well without leaving a bunch of grit at the bottom and I love that it’s simple to add to my daily routine. I’ve been using it consistently and have noticed a difference in my strength during my workouts and I don’t bloat on this product like I do with other creatine brands I’ve tried. Overall it is great quality and worth the price!
MackenzieVerified buyer
★★★★★★★★★★
I am truly enjoying this creatine so far. I definitely feel a significant boost in muscle endurance and cognitive function. I recommend this product
MateenVerified buyer
★★★★★★★★★★
This is hands down the best creatine I’ve tried. It dissolves with no taste—I put it in my tea or coffee every morning and even in plain water if I’m doing another 5g at night.
MiaVerified buyer
★★★★★★★★★★
Incredible creatine! I've had Momentus, Thorne, and a few other brands but ANTI Labs beats all of them in taste and feeling. Highly recommend! (Also the bag is cool which is a plus)
ElliottVerified buyer
★★★★★★★★★★
My shipment arrived quickly and was in perfect condition. I love that it came in a bag (that looks awesome) and not a bulky plastic jug. This creatine is the best I've purchased as others were very bitter and it was difficult to hide the taste. This is so much better that I can put it in a glass of water and only get the slightest taste. This will be my go-to from here on.
KarenVerified buyer
★★★★★★★★★★
Best creatine out there! I have tried them all and this one is my favorite. It mixes well with anything and is just part of my daily routine now. Love this stuff!
HaydenVerified buyer
★★★★★★★★★★
I’ve been really happy with AntiLabs creatine powder! It mixes well without leaving a bunch of grit at the bottom and I love that it’s simple to add to my daily routine. I’ve been using it consistently and have noticed a difference in my strength during my workouts and I don’t bloat on this product like I do with other creatine brands I’ve tried. Overall it is great quality and worth the price!
MackenzieVerified buyer
★★★★★★★★★★
Excellent product. Kind of unbelievable how clean the taste is and got to speak with the founders they are OBSESSIVE about quality. After personally meeting them I have even more trust in these products and I’ll never switch to another brand.
EitanVerified buyer
★★★★★★★★★★
Believe me when I say I did not expect a creatine to change my whole morning, and yet here we are. I'm a mom of two and I've been lifting consistently for ten years, which means I've choked down more chalky, gritty, floating-on-top-of-the-water creatine than I care to admit. The kind that you painstakingly chug, and there's still a little sand dune of undissolved powder waiting for you at the bottom.
Well, not this one. It is the most fine powder that dissolves perfectly into just a few ounces of water. No grit, no clumps, no gross sandy last sip. For the first time in a decade I don't have to psych myself up to take my creatine, so I'm actually take it. I'm 30 days in and I've been more consistent with this one than any creatine I've ever used. I've even started going to the gym 4 days a week, and I haven't gone more than 3 since having kids. Also, ZERO stomach issues! none of the GI problems or bloating I've dealt with from other creatine brands.
My only complaint is that my husband has started stealing it. He has his own creatine sitting right there in the pantry, untouched and dbandoned. Because he decided mine is better and now we're apparently sharing a bag I did not agree to share. So if you buy this, maybe buy two. One for you, and one for the person in your house who's about to develop a sudden interest in your supplements.
GwenVerified buyer
★★★★★★★★★★
Best creatine I’ve had. I usually struggle with digesting creatine as it gives me nausea. This is the first creatine that I’ve had that I’m able to consume and process totally fine. Strongly recommend you try it if you’ve had similar experiences with your body reacting to creatine in the past.
ArmandVerified buyer
★★★★★★★★★★
Love how simple and straightforward this is! I’ve been wanting to add creatine to my routine, and finding one from a brand that is so thoughtful about ingredients and testing was great. Really appreciate knowing exactly what I’m taking and excited to keep using it. Thank you!!
TiffanyVerified buyer
★★★★★★★★★★
Really impressed with this creatine. The powder is extremely fine, mixes quickly without leaving much grit behind, and the unflavored formula makes it easy to add to anything. I also like that it contains just one ingredient and is third-party tested for purity and contaminants. It feels like a well-made, dependable product, and I would buy it again.
AlexanderVerified buyer
★★★★★★★★★★
Pure creatine that I trust. It is flavorless and mixes well.
JoshVerified buyer
★★★★★★★★★★
Awesome product. Feeling stronger, fitter, and fuller since I started using this. All the benefits with none of the fillers and junk that other brands include. Will definitely purchase again or get a subscription.
ChristopheVerified buyer
★★★★★★★★★★
Clean ingredients, found my creatine to keep!
BorisVerified buyer
★★★★★★★★★★
This is the real deal. Best ingredients make the best product.
Highly recommend.
TimVerified buyer
★★★★★★★★★★
Great Quality Creatine. Mixes Easily & Works!
ChiaoVerified buyer
★★★★★★★★★★
What a fantastic product. Everything from the packaging to the quality of the creatine. I take it every day after I work out - it’s now a staple in my everyday supplement routine.
TylerVerified buyer
★★★★★★★★★★
A great flavourless creatine that you can add to any drink. I would highly recommend this product!
JacobVerified buyer
★★★★★★★★★★
best of the best in terms of product quality and purity. I also love how the product is unflavored with no additional sweeteners.
EliVerified buyer
★★★★★★★★★★
These guys are the real deal. So grateful for the care and quality in every scoop <3
MadelineVerified buyer
★★★★★★★★★★
What an amazing product. I was thrilled from the first taste. Will be buying again and recommending!
MabelVerified buyer
★★★★★★★★★★
I've tried many different creatine brands over the years, and this is easily the best I've used. I appreciate that it's a single, clearly labeled ingredient with no fillers. It dissolves completely with no grit at the bottom of the glass, and the flavor is clean without any gross aftertaste. Highly recommend to anyone serious about their supplement intake.
AndyVerified buyer
★★★★★★★★★★
I started the Enhanced Protocol and I'm feeling sharper and clearer every day
JoeVerified buyer
Frequently Asked Questions
Is it safe for my kidneys?
+
Yes, in healthy adults. It has been studied in trials running as long as five years. One thing worth knowing: creatine nudges serum creatinine up slightly, a breakdown product that can make a routine kidney panel look off without anything being wrong. Tell your physician you supplement so they read the number in context. If you already have kidney disease, talk to them first.
Not in the way most people mean. The early water gain is real: the ISSN's review attributes it primarily to intracellular volume, meaning water drawn into the muscle cell as your stores saturate rather than into the subcutaneous tissue that reads as puffiness. That accounts for the 1 to 2 kg some people see in the first couple of weeks. Over longer periods the picture is quieter, since several studies find no change in total body water relative to muscle mass, so the extra intracellular water simply tracks the muscle you're carrying. It's part of how creatine works, not a side effect.
Yes, and it is a very strong pairing. A 2026 meta-analysis of 20 trials found that a quarter to nearly 40% of the weight lost on GLP-1s is lean mass, and that resistance training cuts that to 17.5% when protein is adequate. Creatine is the most studied supplement in sport, with consistent gains in strength and lean mass in people who train, and there is no known interaction with your medication. A trial in GLP-1 users is now underway and reads out in 2027. Until then, it is a well-evidenced, low-risk addition. One note: creatine slightly raises serum creatinine, so mention it before a kidney panel.
Which form is best: monohydrate, HCl, or ethyl ester?
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Monohydrate. Head-to-head, HCl came out equivalent: across eight weeks of resistance training it matched monohydrate on strength, hypertrophy, and hormonal response, with no advantage over it. Ethyl ester did worse: it was less effective at raising serum and muscle creatine than monohydrate. Equivalent at best, then, and the premium forms mostly exist to justify a bigger margin. We use creatine monohydrate, the form nearly every major clinical trial has actually run on.
CM-01 uses Creavitalis®, made by AlzChem, the manufacturer of Creapure®, at its production facility in Trostberg, Germany. Creavitalis® is AlzChem's newest creatine line. It is held to the same purity standard as Creapure® and is ultra-micronized, so it mixes more easily and tastes lighter.
Will creatine make me lose my hair?
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No. A 2025 randomized trial measured hair-follicle density and DHT across 12 weeks on creatine and found no difference from placebo. The whole worry traces to a single 2009 study of twenty rugby players that saw a temporary rise in DHT, not hair loss, and even that has never been replicated.
In three layers. First, manufacturing: our U.S. manufacturing facility is FDA-registered, NSF-certified and cGMP-certified, with verification steps throughout production. Second, independent testing: every finished lot is tested by an ISO 17025 accredited third-party laboratory for identity, purity, heavy metals, and microbial safety. Third, transparency: we publish the full results for every batch on our testing page, so you can look up the lot number printed on your pouch and read the measured values yourself.
Can I see the test results for my specific lot?
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Yes. Every finished lot is tested by an ISO 17025 accredited third-party laboratory, and we publish the full result for each one on its own page, so you can read the measured values for the exact lot in your bag before you buy it. Our current batch is lot 60497, where you can see the identity, heavy-metal and microbiological results next to the specification each one had to clear. Lot 60497 was tested by Swift Laboratory (an ISO 17025-accredited third-party lab). Every published batch is listed on the testing page.
Is ANTI Labs NSF certified?
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Not currently. We're in the process of NSF product certification and look forward to adding one more independent check. Our products already go through several. They're made in our U.S. manufacturing facility, which is NSF-certified, FDA-registered and cGMP-certified, with identity and quality checks at multiple steps of production, and every finished lot is independently tested by an ISO 17025 accredited laboratory for identity, heavy metals, and microbials. We publish the complete numerical results for each batch, so you can look up the exact lot in your hands. If you compete under a governing body that requires NSF Certified for Sport products, check its rules before supplementing.
Does creatine cause renal injury?
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No. A 2025 systematic review of 21 studies, 12 of them pooled for meta-analysis, found no significant change in GFR or renal function markers from creatine supplementation. Long-term safety has been examined in controlled trials extending to five years. The original concern traces to two late-1990s case reports that have not been substantiated in subsequent prospective trials.
How should we interpret the serum creatinine elevation in supplementing patients?
+
Serum creatinine rises 10 to 20% from supplementation itself, a metabolic byproduct of creatine breakdown, not a damage marker. BUN, cystatin C, and the BUN:creatinine ratio remain unchanged, distinguishing supplementation-driven elevation from renal injury. For patients where renal monitoring is clinically important, cystatin-C-based eGFR avoids the creatinine confound.
How should we counsel patients with stage 2 to 3 CKD?
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We default to deferring: discuss with the patient's nephrologist before initiating. The literature in healthy populations doesn't extrapolate cleanly to compromised renal function, and serum creatinine elevations from supplementation can confound monitoring. For stage 1 with stable function and no other risk factors, baseline + 12-week eGFR and cystatin C are reasonable.
What's the sourcing standard and analytical purity for CM-01?
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We source micronized creatine monohydrate at ≥99.9% purity by HPLC. Manufacturing-byproduct specifications include dicyandiamide ≤50 mg/kg, dihydrotriazine <3 mg/kg, and residual creatinine <100 mg/kg. Heavy metals (As, Cd, Pb, Hg) each at <0.1 mg/kg. Every incoming lot is re-verified via third-party ISO 17025 lab, with numerical results published on the lot registry.
What's your 60-day guarantee?
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Every order is covered by a 60-day guarantee. If you're not satisfied, return it within 60 days of delivery for a refund or replacement, for any reason. Full details are in our Refund Policy. Start a return through our returns portal.
How fast do you ship, and where?
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We ship within the United States. Orders ship from our US fulfillment center within 1 business day.
In our U.S. manufacturing facility, which is NSF-certified, UL-registered, SQF-certified and GMP-certified.
How do you decide what to sell?
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We review ingredients rigorously and publish our reasoning in the Formulary. We only sell what we'd take ourselves. Of the ingredients we've reviewed, we've rejected 95%.
How do your physicians review a product?
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In three steps. First, Aaron Esagoff, MD (Johns Hopkins School of Medicine) reviews the clinical evidence and decides whether the ingredient is worth selling, in what form and at what dose. Second, every physician on our medical advisory board reviews it independently. All of them must agree that the evidence is clear and supports safety and efficacy across a robust set of human trials, that the dose and form match the evidence, and that they support the exact version we sell. Third, once it is sourced and produced, the board signs off again on its sourcing, our manufacturing quality and its independent test results. Final sign-off takes a unanimous board. See the full review process.
What is ANTI Labs' testing process?
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Every lot goes through three distinct stages of testing. The raw ingredient is tested before it ships to our manufacturing facility, tested again when it arrives, and the finished product is tested once more after it is filled. Every lot's results are published on our testing page.
What happens if a lot fails testing?
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We don't sell it. Every lot is tested against our stringent limits. If a result comes back outside a limit, we retest to verify. If it is still out of spec after retesting, the lot is rejected and never sold. See how testing works on our testing page.
The brain takes up creatine more slowly than muscle and sits behind the blood-brain barrier, so raising brain creatine takes more sustained intake than saturating muscle does. That is why research into creatine's cognitive and brain-energy effects leans on higher daily doses, an approach with a long, well-documented safety record in healthy adults. The evidence is still emerging and strongest under mental stress, sleep loss, and fatigue, which is why we make the higher dose our default.
